The story is about a scientist named Griffin. He had been discovering ways which could make a man invisible and finally swallowed certain rare drugs that made him invisible. He was first noticed by two boys in staircase of a house where they could just see his footsteps and started following it. They follow it until the footsteps are fainter and cannot be seen. First as he is feeling cold he enters a mall for some warmth. After the stores shutdown he decides to wear some warm clothes and eat something. He first unboxes a few clothes and wears them. Then from the kitchen of a restaurant he eats cold meat and some coffee. Later he goes to a grocery store and eats sweets and drinks wine. He then falls asleep on a pile of quilts. He then wakes up in the morning when some of the store assistants had seen him and started chasing him. He quickly threw away all the clothes he was wearing and became invisible again. Then he started roaming around again without any clothes in the cold winters of London. He then decides to steal clothes from a theatre company as he knew he would get something there to cover his face as well. He then steals bandages for his face, dark glasses, false nose and a hat for covering himself. He then hits the shopkeeper and steals all his money. Soon he realizes that London is too crowded to live like this and decides that he would go to a remote village. He books two rooms at an inn at the Iping village.
He reaches there and it is strange for the people of Iping that a stranger with such a weird appearance has come to stay at an inn during the winter season. Once his money is over, he steals from people and also hits the landlord and his wife when they try to check his room in his absence. Then the village constable is asked for help but before that Mrs. Hall, the wife of the landlord asks him questions regarding who he is and what he did to her furniture. This makes him really furious and he decides to show her who he really is. The people then see a headless man and Mr. Jaffers, the constable also finds out that he would have to arrest a man who does not have a head. They are unable to catch Griffin as he removes all his clothes and becomes invisible. He even knocks out Jaffers as he tries to catch him.